clinical studies

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*ProSource TF can be administered in multi packet doses.  We recommend administering no more than 3 packets at one time.

Nutrition Therapy in the Patient with COVID-19 Disease Requiring ICU Care

Updated April 1, 2020

Recommendation 4: Nutrition Dose, Advancing to Goal, and Adjustments

Feeding should be initiated with low dose EN, defined as hypocaloric or trophic, advancing to full dose EN slowly over the first week of critical illness to meet energy goal of 15-20 kcal/kg actual body weight (ABW)/day (which should be 70-80% of caloric requirements) and protein goal of 1.2-2.0 gm/kg ABW/day.

Meeting protein provisions for the mechanically ventilated patient

The Issue:

The COVID-19 virus has brought significant new challenges to the nutritional support of the estimated 960,000 patients who will require mechanical ventilation.

Overview:

Ventilated patients are anesthetized using a lipid (fat) based anesthesia such as propofol that typically delivers 400-500 fat calorie per day. Enteral tube feeding formulas do not deliver enough protein to meet the Society of Parenteral and Enteral Nutrition (ASPEN) guidelines of 1.2 -2.0 mg of actual body weight per day without over feeding calories.

espen 2016 Critical care: Meeting protein requirements without overfeeding Energy

Department of Nutrition & Dietetics, Southmead Hospital, Bristol, United Kingdom by Dr. Stephen Taylor.

Highlights Medtrition’s ProSource® TF was able to meet up to 94% of protein requirements in critical care patients than enteral formula alone. “Complimenting NPP feed to the nearest protein supplement pack, without overfeeding energy, increased the number of prescriptions meeting their respective guidelines by 10e90%; for local guidelines (FeedCalc) it increased from 32% to 73% using Pro-Source® TF or 82% using Prosource® Plus (both p < 0.001).” “Patients most at risk from protein ± glucose ± micronutrients deficits or energy overload are those with relatively low energy requirements due to small body size or being hypocalorically fed or receiving NNE, especially where Propofol displaces protein and carbohydrate. Complete feeds and protein supplements are complimentary. In practice a complete feed that supplies the protein and micronutrient requirements within energy expenditure would be most convenient. However, at present, enteral feeds (or PN solutions) don't adequately account for protein needs and NNE load. In these cases a protein supplement is necessary; protein ± glucose ± micronutrient supplementation may be needed when feed prescription is very limited.”

THE CLINICAL AND ECONOMIC IMPACTS OF USING SUPPLEMENTAL ENTERAL NUTRITION FORMULAS IN HOSPITALIZED PATIENTS WHO ARE TAKING TOTAL PARENTERAL NUTRITION

INTERNATIONAL JOURNAL OF CURRENT MEDICAL AND PHARMACEUTICAL RESEARCH -King Hussein Medical Hospital, King Abdullah II St 230, Amman 11733, Jordanian Royal Medical Services by Dr. Mahmoud Bani Younes.

Highlights Medtrition’s ArgiMent® AT (Advanced Therapy) - “Across all analysis variables in our study, ArgiMent® had the highest significant positive clinical and economic outcomes due to the unique formulation characteristics of very high PD (≈26 g/100 Cal), High PRO quality (10 g of whey protein (WP)) ,high CD (≈2 Cal/ml), enrichment of immune enhancing nutrients (IENs) of GLT, arginine (ARG), and vitamin C, enrichment of prebiotic galcto-oligosaccharides (GOS or Bimuno), and enrichment of zinc which might also explain the significant highest liver ALB synthesis in short bowel syndrome (SBS) or other TPN indication scenarios in hospitalized patients with highly suspected zinc deficiency.”

The clinical and economic impacts of using high caloric and protein specialized versus standard nutritional enteral formulas in hypoalbumenic hospitalized patients

INTERNATIONAL JOURNAL OF CURRENT MEDICAL AND PHARMACEUTICAL RESEARCH -King Hussein Medical Hospital, King Abdullah II St 230, Amman 11733, Jordanian Royal Medical Services by Dr. Mahmoud Bani Younes.

Highlights Medtrition’s RenaMent® Raspberry Creme Flavor Powder Supplement - “The high protein biological value (BV) protein of RenaMent® may explain the significant higher difference of % change in albumin and % change in body weight when compared with other standard enteral nutrition formulas (ENFs). Ultimately, if we conserve albumin and lean body mass (LMB) from catabolism as possible, the consequences of morbidities and mortalities are expected to be lower and this correlation may explain the lower overall 28-day hospital mortality and overall hospital length of stay (LOS) in Group II (who took RenaMent®) compared with Group I (who was not taking RenaMent®).”